Written Resources | RATIONAL-PT

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RATIONAL Platform Trial

Published Resources

Immunoglobulin replacement vs prophylactic antibiotics for hypogammaglobulinemia secondary to hematological malignancy

Professor Zoe McQuilten

15th November 2023

Findings from the randomized controlled RATIONAL feasibility trial which supported the initiation of a larger phase 3 clinical trial

Immunoglobulin use, survival, and infection outcomes in patients with chronic lymphocytic leukemia

Dr Sara Carrillo de Albornoz

28th October 2025

This study describes IgRT treatment patterns in a large, real-world cohort of patients with CLL, and explores the association between IgRT and serious infections

Variation in immunoglobulin use and impact on survival in myeloma

Dr Khai Li Chai

16th June 2024

This study investigated immunoglobulin use in Australia, New Zealand and Asia-Pacific using registry data of MM patients and exploring the association with survival outcomes.

Trial Documents

RATIONAL Platform Trial summary page

A summary document explaining the key concepts of the trial and covering some frequently asked questions

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